Diego de Arce y Reinoso Ávila y Palomares (25 April 1587 – 18 July 1665) was a Spanish bishop who served as Grand Inquisitor of Spain from 1643 to 1665; and as Bishop of Plasencia (1640–1652), Bishop of Ávila (1637–1640), and Bishop of Tui (1635–1637).