Ambrose Agius, O.S.B., (September 17, 1856 – December 13, 1911) was a Maltese Archbishop of the Roman Catholic Church.
A member of the Benedictine Order, Agius served under the pontificate of Pope Leo XIII and was appointed the Apostolic Delegate to the Philippines by Pope Pius X in 1904.
Agius was delegated to canonically crown the image of Our Lady of La Naval de Manila in 1907.
More prominently, he founded the first Benedictine monastery in Malta, and ordained the first Filipino bishop in the Roman Catholic Church.