"Duke" Nelson (April 26, 1907 – October 22, 1989) was an American college athletics coach and administrator.
He served as the head football coach at Rensselaer Polytechnic Institute (RPI) from 1939 to 1941 and at Middlebury College from 1946 to 1968 compiling a career college football coaching record of 98–81–12.
At Middlebury, he teams won back-to-back Vermont State Conference championships in 1948 and 1949.