Marco Macina (born 30 September 1964) is a Sammarinese former footballer.
One of only two Sanmarinese players to appear in the Italian Serie A (the other being Massimo Bonini), playing alongside Roberto Mancini with Bologna, Macina was not able to fully show his potential, despite having been signed by AC Milan in 1985.
He left professional football in 1988, after a Serie C season with Ancona.
Macina also played two European Cup qualifying matches for San Marino in 1990.