He moved to Cádiz, the seafaring gate of trade to the American Spanish Empire and earned a doctorate of divinity in nearby Jerez de la Frontera in 1767 He became a prior to sieges of the Dominican Order in Málaga, AlmerĂa, Cabra, Ciudad Real and Doña MencĂa, training teachers of Christianity, dictionary editors and administrative tutors in aboriginal American Indian languages, North and South America, after the middle of the 16th Century.
In 1788 Charles III of Spain proposed to Pope Pope Pius VI that Portillo be chosen as Archbishop of Santo Domingo, the primate siege of America, created in 1546.
Difficulties on the Island of Hispaniola around 1798 led him to move the supposed remains of seafarer and discoverer Christopher Columbus to La Habana, Cuba, being kept at the Convent of San Juan de Letrán.
Portillo was proposed by the Spanish Crown to the Roman Pope in 1798 as a Bishop of Trujillo, Peru, but instead Portillo became Archbishop of Bogotá, a much higher position.
Del Portillo y Torres died in 1804, aged around 75.