Antonio Farnese (29 November 1679 – 20 January 1731) was the eighth and final Farnese Duke of Parma and Piacenza.
He married, in 1727, Enrichetta d'Este of Modena with the intention of begetting an heir.
The marriage, however, was childless, leading to the succession of Charles of Spain, whose mother, Elisabeth Farnese, was Antonio's niece, to the ducal throne.