María José Portillo Ramírez (born 8 May 1999) is a Mexican tennis player.
She has a career high WTA singles ranking of 808, achieved on 28 May 2018.
She also has a career high WTA doubles ranking of 441, set on 18 June 2018.
Portillo Ramírez has won one ITF singles titles and seven ITF doubles titles.
She has represented Mexico at the Fed Cup, where she has a win-loss record of 2–0.