Ippolito (II) d'Este (25 August 1509 – 2 December 1572) was an Italian cardinal and statesman.
He was a member of the House of Este, and nephew of the other Ippolito d'Este, also a cardinal.
He is perhaps best known for his despoliation of the then 1,400-year-old Hadrian's Villa, built by the Roman emperor Hadrian, removing marbles and statues from it to decorate his own villa, the Villa d'Este.