George William Spencer Lyttelton CB FRGS (12 June 1847 – 5 December 1913) was an English civil servant from the Lyttelton family who acted as private secretary to William Ewart Gladstone during three of his terms as Prime Minister of the United Kingdom.
He was also one of eleven members of the Lyttelton family to play first-class cricket; primarily for Cambridge University during his time studying there.