Giles Mutsekwa (born 14 September 1948) is a Zimbabwean politician.
He was appointed to the unity government as one of two co-ministers of Home Affairs by Prime Minister Morgan Tsvangirai in February 2009 and sworn into office on February 13.
He concurrently served as secretary for Security and Intelligence of the MDC-T, and served as MP for Mutare North from 2000 to 2008.
In 2010, he was reassigned and became Minister for Housing.