Seraph Frissell, M.D., (August 20, 1840 – 1915) was an American physician and medical writer.
She specialized in diseases of women and children.
She was the first woman in Western Massachusetts to be admitted to any district medical society, and the fourth woman to be admitted a member of the Massachusetts Medical Society.
Women were first admitted to medical societies in Massachusetts in 1884; but the Berkshire District Medical Society made Frissell an honorary member in 1877, and she attended its monthly meetings, receiving notices as a regular member.