One of the early American abolitionists, Benezet founded one of the world's first anti-slavery societies, the Society for the Relief of Free Negroes Unlawfully Held in Bondage (after his death it was revived as the Pennsylvania Society for Promoting the Abolition of Slavery); the first public school for girls in North America; and the Negro School at Philadelphia, which operated into the nineteenth century.
He was a vegetarian and advocated for the kind treatment of animals; integrating this in his teachings.