Prince Karl Anton of Hohenzollern-Sigmaringen (German: Karl Anton Joachim Zephyrinus Friedrich Meinrad Fürst von Hohenzollern-Sigmaringen) (7 September 1811 – 2 June 1885) was head of the Princely House of Hohenzollern-Sigmaringen, Hohenzollern from 1869 and Prime Minister of Prussia.
He was the son of Karl, Prince of Hohenzollern-Sigmaringen, who abdicated in favour of his son on 27 August 1848, and his first wife Marie Antoinette Murat, niece of Joachim Murat.