He has also branched out into more traditional presenting roles, on weather phenomena and wildlife documentaries on the BBC and Channel 5.
In 2007 he directed A Very British Gangster, which premiered at the Sundance Film Festival.
From April 2010, MacIntyre presented ITV's local news show London Tonight, departing after only a few months after taking up the post.In 2009, MacIntyre took part in the fourth series of Dancing on Ice, where he was runner-up to Ray Quinn.
In 2014, he participated in the first series of The Jump where he was runner-up to Joe McElderry.
MacIntyre currently fronts the CBS Reality documentary series Donal MacIntyre: Unsolved, which looks at unsolved cases such as abductions and murders, that MacIntyre and his team try to shed new light upon.