Nicola Ascoli (born 11 September 1979 in Vibo Valentia) is a retired Italian footballer who played as a defender.
He spent most of his career playing in Serie B and Serie C.
In 2012, Ascoli became the director of sport at Serie D side Asti and joined the coaching staff under Enrico Pasquali after obtaining his coaching license.Ascoli is married to Alessandra Sinopoli, sister-in-law of Juventus and Italy midfielder Claudio Marchisio, his teammate for a season at Empoli.