Luis Colosio Fernández (2 March 1923 – 6 February 2010) was a Mexican politician affiliated with the Institutional Revolutionary Party (PRI).
He served as Senator of the LVIII and LIX Legislatures of the Mexican Congress representing Sonora.He was father of Luis Donaldo Colosio, presidential candidate of the PRI in the 1994 election who was murdered on 23 March 1994.