Antonio Zapata y Cisneros, also listed as Zapata y Mendoza, (Madrid, 8 October 1550 – Madrid, c.
27 April 1635) was a Spanish bishop.
He served as bishop of Cádiz and Pamplona, archbishop of Burgos, cardinal, councillor of state for Philip III, Viceroy of Naples, and Inquisitor General of the realm.