Isaac Romo González (born March 23, 1983 in Guadalajara, Jalisco) is a former Mexican footballer, who last played for Leones Negros UdeG in the Ascenso MX.
Romo played for Chivas USA of Major League Soccer, arriving as one of imports from parent club Chivas de Guadalajara, and also played for their other child club, La Piedad.
He played for the Mexico U-20 team at the 2003 World Youth Championship in the United Arab Emirates.
Romo was released by Chivas USA following the 2005 season.