Rosa María Leal de Pérez (born 9 December 1953) is a Guatemalan psychologist.
She is married to Otto Pérez Molina, former President of Guatemala, thus making her the First Lady of the Republic of Guatemala from 14 January 2012 to 3 September 2015.She was a kindergarten teacher for a period of four years, from 1975 to 1979, is a technician in psychometrics and school orientation, and has a degree in clinical psychology from the Rafael Landívar University.
From 1980 to 1995, Leal was Director of the National Primary Education, specializing in nursery school.