Jaco Nepgen (born 3 January 1986) is a former South African rugby union footballer that played as either lock or flank.
He represented Griquas in the Currie Cup and Vodacom Cup competitions between 2010 and 2016, played a single match for the SWD Eagles in the Currie Cup and won back-to-back titles with Maties in the Varsity Cup in 2008 and 2009.
He also represented South Africa Universities in 2008 and 2009.
He retired in July 2016 following doctor's advice, having made 90 first class appearances.