Gaspar de Borja y Velasco (26 June 1580 – 28 December 1645) was a Spanish cardinal, ecclesiastic and politician.
He belonged to the house of Borgia (though he always used the Spanish spelling of Borja) and served as Primate of Spain, Archbishop of Seville, Archbishop of Toledo and viceroy of Naples.
He was the great-great-great-great-grandson of Pope Alexander VI.