"Biffy" Lee (September 27, 1887 – April 10, 1970) was an American football player and coach.
He served as the head football coach at Penn College—now known as William Penn University—in Oskaloosa, Iowa in 1915 and again from 1917 to 1920 and at the University of Buffalo—now known as University at Buffalo—from 1929 to 1930, compiling a career college football record of 17–20–4.