John O'Keefe (11 January 1880 – 27 January 1942) was an Australian politician.
He was a Labor member of the Legislative Assembly of Queensland, representing Chillagoe from 1926 to 1929 and Cairns from 1930 to 1942.
He was Attorney-General from 1940 to 1941.O'Keefe died in office in 1942 and following his funeral at St Stephen's Cathedral was buried in Nudgee Cemetery.