Jéssica Adriana Guillén Blanco (born March 27, 1985, in Caracas, Venezuela) is a Venezuelan beauty pageant titleholder who represented Amazonas in Miss Venezuela 2009, on September 24, 2009, and won the title of 2nd runner up.
Guillén also competed in Chica E! Venezuela 2008 pageant on August 7, 2008 in Caracas, Venezuela.She won the Miss Atlantico Internacional 2010 pageant ("Miss Atlantic International"), in Punta del Este (Uruguay), on January 23, 2010.