Koo Tsai Kee (simplified Chinese: ???; traditional Chinese: ???; pinyin: Gù Cà iji) is a Singaporean associate professor and former politician.
He was a Member of Parliament from 1991 to 2011, representing the Tiong Bahru division under the Tanjong Pagar Group Representation Constituency (Tanjong Pagar GRC).
While he retired, his constituency was merged into Tanjong Pagar and renamed to Tanjong Pagar-Tiong Bahru.