Kyle Derrick Williams (born June 10, 1983) is a former American football defensive tackle who spent his entire 13 year career with the Buffalo Bills of the National Football League (NFL).
He played college football at LSU, and was drafted by the Bills in the fifth round of the 2006 NFL Draft, playing 13 seasons with them before retiring following the 2018 season.
At the time of his retirement, Williams ranked fifth in Bills history in tackles and sacks (first overall in sacks among defensive tackles), and made six Pro Bowls.
He was described by the Associated Press as "the heart and soul" of the Bills during his time there.