Wilhelm, Duke of Saxe-Weimar (Altenburg, 11 April 1598 – Weimar, 17 May 1662), was a duke of Saxe-Weimar.
Wilhelm was the fifth (but third surviving) son of Johann, Duke of Saxe-Weimar, and Dorothea Maria of Anhalt.
He was brother to Bernard of Saxe-Weimar, a successful Protestant general in the Thirty Years' War, and to Ernest I, Duke of Saxe-Gotha (later Altenburg), a successful and well regarded ruler known as "The Pious".