Lewis Albert Sayre (February 29, 1820 – September 21, 1900) was a leading American orthopedic surgeon of the 19th century.
He performed the first operation to cure hip-joint ankylosis (stiffness) and introduced the method of suspending the patient followed by wrapping the body to correct spine distortions.
He was also noted for improving sanitary conditions in New York and stopping the spread of cholera from incoming ships.
Sayre was a principal founder of the Bellevue Hospital Medical College and of the American Medical Association, of which he was elected vice-president in 1866, and president in 1880.