Paul Depaepe (born 12 October 1931) is a former Belgian professional cyclist and world champion.
He competed in the 4,000 metres team pursuit event at the 1952 Summer Olympics.
He competed in motor-paced racing in the professionals category and won the European championships in 1961–1963 and the world championships in 1957; he finished in second place in the world championships in 1961–1963.
He retired in 1965 after a serious back injury during training.In 1946–1947 he was a successful cross country runner, but changed to cycling.
As a road cyclist he competed in 23 six-day races, with the best result of second place in the race of Antwerp in 1959.
He is married to Liane and had a son who died in 2001.