Princess Charlotte Luise Friederike Amalie Alexandrine of Saxe-Hildburghausen, full German name: Charlotte Luise Friederike Amalie Alexandrine, Prinzessin von Sachsen-Hildburghausen (28 January 1794, Hildburghausen, Saxe-Hildburghausen – 6 April 1825, Biebrich, Duchy of Nassau) was a member of the House of Saxe-Hildburghausen and a Princess of Saxe-Hildburghausen (and later of Saxe-Altenburg) by birth.
Through her marriage to William, Duke of Nassau, Louise was also a member of the House of Nassau-Weilburg and Duchess consort of Nassau.
Louise was briefly Princess consort of Nassau-Weilburg in 1816.