Luigi Antonini (1883–1968), a United States Trade union leader, was the first Vice President of the International Ladies' Garment Workers' Union, and organizer of the Italian-American Labor Council (IALC).
He was one of the first to organize the Italian-American anti-fascist movement.
Antonini joined the Anti-Fascist Alliance of North America in 1923.
The group revolved around a newspaper published in New York, Il Nuovo Mondo.