Mariano Ponce (March 22, 1863 – May 23, 1918), was a Filipino physician, writer and active member of the Propaganda Movement.
In Spain, he was among the founders of La Solidaridad and Asociacion Hispano-Filipino.
Among his significant works was Efemerides Filipinas, a column on historical events in the Philippines which appeared in La Oceania Española (1892–1893) and El Ideal (1911–1912).
He wrote Ang Wika at Lahi (1917), a discussion on the importance of a national language.
He served as Bulacan's representative to the Philippine Assembly.