At the age of 26 she launched a dressmaking business on what would become the De Maisonneuve Boulevard.
She received publicity early on through her participation in a charity fashion show at the Windsor Hotel, and after a trip to Paris where she visited several fashion salons, she came back to launch her own fashion salon at 648 Sherbrooke Street West, Montreal in 1936.
In 1962, Nolin lost a lot of her work in a house fire, and subsequently relocated to 420 Bonsecours Street.
In 1969 she launched a ready-to-wear line, although her refusal to compromise by using cheaper fabrics led to the failure of the venture.Marie-Paule Nolin retired in 1974, and closed her business, which was the last couture establishment in Montreal.In 1984, a major retrospective of her work was presented by the McCord Museum in Montreal.
The Museum also manages the Marie-Paule Nolin Study Award, an academic award whose aim is to support fashion and textile research projects which make specific use of the McCord's collections.