Mikuláš Medek (November 3, 1926 - August 23, 1974) was a Czech painter.
He was a grandson of the impressionist painter Antonín Slavícek, son of the General of the Czechoslovak Army and Catholic writer Rudolf Medek and brother of the journalist Ivan Medek.
He is considered one of the most important representatives of Czech modern painting and one of the most important exponents of the post-war period.
He was the husband of the photographer Emila Medková.
During the Communist regime in Czechoslovakia, the general hostility towards modern art and free thinking clashed with his artistic independence and the spiritual dimensions of his works leading to a long lasting ban on displaying his works.
The first full exhibition was realised only in 2002 in the Rudolphinum gallery in Prague.
A selection of his works had been exhibited in a local gallery in Roudnice nad Labem in 1989 with no public notice.