Mohamed Ikoki Msandeki (born December 31, 1985 in Kondoa) is a Tanzanian marathon runner.
He set his personal best time of 2:11:01, at the 2010 Gutenberg Marathon in Mainz, Germany Msandeki represented Tanzania at the 2012 Summer Olympics in London, where he competed for the men's marathon, along with his compatriots Samson Ramadhani and Faustine Mussa.
However, he withdrew from the games on the day before the marathon event, because of illness.