Frederick Augustus, Prince of Anhalt-Zerbst (8 August 1734 in Alt Stettin – 3 March 1793 in Luxembourg), was a German prince of the House of Ascania and the last ruler of the Principality of Anhalt-Zerbst.
He was the second and sole surviving son of Christian Augustus, Prince of Anhalt-Zerbst (since 1742 of all Anhalt-Zerbst) by his wife Johanna Elisabeth of Holstein-Gottorp, daughter of Christian August of Schleswig-Holstein-Gottorp, Prince of Eutin, and was a younger brother of Russia's Catherine the Great.