Christian II of Anhalt-Bernburg (11 August 1599, in Amberg – 22 September 1656, in Bernburg), was a German prince of the House of Ascania and ruler of the principality of Anhalt-Bernburg.
He was the second (but eldest surviving) son of Christian I, Prince of Anhalt-Bernburg by his wife Anna of Bentheim-Tecklenburg, daughter of Arnold III, Count of Bentheim-Steinfurt-Tecklenburg-Limburg.