Duchess Therese Mathilde Amalie of Mecklenburg-Strelitz (German: Herzogin Therese Mathilde Amalie zu Mecklenburg-Strelitz; 5 April 1773 – 12 February 1839) was a member of the House of Mecklenburg-Strelitz and a Duchess of Mecklenburg.
Through her marriage to Karl Alexander, 5th Prince of Thurn and Taxis, Therese was also a member of the House of Thurn and Taxis.