From 2014 until May 2019, she was senior pastor of New Destiny Christian Center, in Apopka, Florida, a non-denominational, multicultural megachurch.
She was formerly the co-pastor of Without Walls International Church in Tampa, Florida, a church she co-founded with pastor and then-husband Randy White in 1991.
She hosts a television show, Paula White Today.
White became chair of the evangelical advisory board in Donald Trump's administration.
She delivered the invocation at his inauguration, on January 20, 2017.
She is the first female to deliver the invocation.
She was listed number three on the "50 Most Powerful 2017: Philanthropy & Community Voices" list in the Orlando Magazine July 2017 issue.
In November 2019, Trump appointed White as special adviser to the Faith and Opportunity Initiative at the Office of Public Liaison.