William Lewis Sublette, also spelled Sublett (September 21, 1798 - July 23, 1845), was an American frontiersman, trapper, fur trader, explorer, and mountain man.
With his four brothers, after 1823 he became an agent of the Rocky Mountain Fur Company.
Later he became one of the company's co-owners, exploiting the riches of the Oregon Country.
He helped settle and improve the best routes for migrants along the Oregon Trail.