Princess Sophie Friederike Karoline Luise of Saxe-Coburg-Saalfeld (19 August 1778 – 9 July 1835) was a princess of Saxe-Coburg-Saalfeld, and the sister of Princess Victoria of Saxe-Coburg-Saalfeld and King Leopold I of Belgium, and aunt of Queen Victoria.
By marriage, she was a Countess of Mensdorff-Pouilly.
She was born in Coburg, the eldest child of Francis, Duke of Saxe-Coburg-Saalfeld and Countess Augusta Reuss of Ebersdorf.