His book The Challenges of Economic and Institutional Reforms in Africa influenced practical policy directions on an array of areas during the turbulent 1980s and 1990s.
Saitoti joined politics as a nominated Member of Parliament and Minister for Finance in 1983, rising to become Kenya's longest-serving Vice-President, a proficient Minister for education, Internal Security and Provincial Administration and Foreign Affairs.
Few recognise him as a "reformist", but his recommendations as the Chair of the KANU Review Committee, popularly known as the "Saitoti Committee" in 1990–91, opened KANU to internal changes and set the stage for the repeal of Section 2A and Kenya's return to pluralist democracy.
Saitoti left KANU and joined the opposition, becoming a kingpin figure in the negotiations that led to the "NARC Revolution" in 2002.
As Minister for Internal Security and Provincial Administration, Acting Minister for Foreign Affairs and key member of the National Security Advisory Committee (NSAC), he later worked closely with the national Ministry of Defence to see through the Operation Linda Nchi against the Al-Shabaab insurgent group.
In addition, rival factions had for decades invoked the infamous Goldenberg fraud to knock Saitoti out of politics, but the legal courts cleared him of the scandal in July 2006.
Saitoti's dual heritage as a Maasai with Kikuyu family members predisposed him to a pan-Kenyan vision, but also denied him a strong ethnic base unlike his competitors.
As one of Kenya's most experienced, unassuming and shrewd politicians, Saitoti was billed as a front-runner in the race to succeed President Mwai Kibaki.