Robert MacFarlan Cole (December 26, 1889 – January 18, 1986) was an American chemical engineer, inventor, and author.
He helped develop many chemicals, including freon and its use as a refrigerant and an aerosol repellent, a substance to counteract poisonous gas in World War I, synthetic rubber and pyrethrin insecticides in World War II, and ethylene oxide as a hospital germicide.