Ryuzo Yanagimachi (?? ??, Yanagimachi Ryuzo, born August 27, 1928) is a Japan-born American-based scientist.
He has made numerous key contributions to the study of mammalian fertilization.
He is a pioneer of assisted fertilization technologies such as in vitro fertilization and direct sperm injection into egg (commonly called intracytoplasmic sperm injection or ICSI) which are widely used today in human infertility clinics throughout the world.
He was also a pioneer in the cloning field.
In 1997 his laboratory at the University of Hawaii at Manoa successfully cloned mice using the Honolulu technique.
The first one was a female named Cumulina from the cells that surround the developing ovarian follicle in mice.