Santo Santoro (born 27 April 1956) is a former Australian politician and a former deputy leader of the Liberal Party in Queensland.
He was a member of the Legislative Assembly of Queensland from 1989 to 2001; and a member of the Australian Senate from 2002 to 2007, representing the state of Queensland.
He resigned from John Howard's ministry and from the Senate in the wake of a number of breaches of the Ministerial Code of Conduct and of the Register of Senators' Interests.