Séamus Prendergast (born 1 January 1980) is an Irish hurler who played as a centre-forward for the Waterford senior team.
Born in Ardmore, County Waterford, Prendergast first played competitive hurling in his youth.
He first arrived on the inter-county scene as a member of various Waterford teams at underage levels.
Prendergast joined the senior panel during the 2001 championship and subsequently became a regular member of the starting fifteen.
He went on to win four Munster medals and one National Hurling League medal.
Prendergast was an All-Ireland runner-up on one occasion.
As a member of the Munster inter-provincial team on a number of occasions, Prendergast won one Railway Cup medal.
At club level he is a two-time championship medallist in the intermediate grade with Ardmore.
His brother, Declan Prendergast, also enjoyed a lengthy career with Waterford.
Throughout his career Prendergast made 58 championship appearances.
He announced his retirement from inter-county hurling on 14 October 2014.