Serge Yoffou (born 24 December 1971 in Abidjan) is a former Ivorian international footballer, who played in his career as a forward.
In his career Yoffou played in his country for Stella d'Adjamé and Stade d'Abidjan, in France for Dijon FCO and Paris FC, in Bulgaria for Dobrudzha Dobrich and Levski Sofia and in Switzerland for FC Baden, SR Delémont, FC Thun and CS Chênois.