Thomas Wylie (June 4, 1841 – July 10, 1915) was an Ontario physician and political figure.
He represented Simcoe West in the Legislative Assembly of Ontario as a Conservative member from 1886 to 1894.
He was born in Toronto in 1841, the son of John Wylie, a Scottish immigrant.
Wylie studied medicine at John Rolph's Toronto School of Medicine, graduating with an M.D.