Wayne Anthony Smith (born November 17, 1979) is a former professional Canadian football offensive lineman who played in the Canadian Football League (CFL) from 2004 to 2017.
He was drafted first overall by the Hamilton Tiger-Cats in the 2004 CFL Draft and spent four seasons over two stints with the team.
Smith won a Grey Cup championship with the Saskatchewan Roughriders in 2007.
He was also a member of the Toronto Argonauts of the CFL and the Washington Redskins and Denver Broncos of the National Football League.