William Harding le Riche (21 March 1916 – 31 December 2010) was a South African–born Canadian epidemiologist.
He was Professor of Epidemiology (emeritus) at University of Toronto.
Le Riche was born in Dewetsdorp, Orange Free State, Republic of South Africa and first studied at the University of the Witwatersrand in Johannesburg, where he gained a Bachelor of Science (B.Sc.) in 1936.